| Invasive | Borderline | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BMI (kg/m2) | Studies | I2 (%) | Cases | Controls | pOR (95%CI) | Studies | I2 (%) | Cases | Controls | pOR (95%CI) |
| Recent BMI | ||||||||||
| <18.5 | 11 | 26.6 | 183 | 282 | 1.08 (0.84–1.39) | 10 | 0.0 | 57 | 281 | 1.13 (0.82–1.55) |
| 18.5–24.9 (ref) | 11 | 4020 | 6796 | 1.0 | 10 | 1080 | 6599 | 1.0 | ||
| 25–29.9 | 11 | 31.2 | 2500 | 4077 | 1.00 (0.92–1.09) | 10 | 13.8 | 662 | 3930 | 1.23 (1.09–1.39) |
| 30–34.9 | 11 | 0.0 | 1166 | 1808 | 1.06 (0.97–1.16) | 10 | 1.1 | 379 | 1741 | 1.61 (1.40–1.85) |
| 35–39.9 | 11 | 1.7 | 511 | 692 | 1.21 (1.07–1.38) | 10 | 0.0 | 150 | 672 | 1.68 (1.37–2.06) |
| ≥40 | 11 | 0.0 | 383 | 503 | 1.22 (1.05–1.41) | 9 | 0.0 | 137 | 486 | 1.96 (1.57–2.46) |
| Per 5 kg/m2c | 11 | 47.7 | 1.04 (1.00–1.08)* | 9 | 0.0 | 1.18 (1.14–1.23) | ||||
| Maximum BMI | ||||||||||
| <18.5 | 6 | 0.0 | 24 | 33 | 1.22 (0.69–2.14) | 3 | 0.0 | 5 | 19 | 1.00 (0.33–3.03) |
| 18.5–24.9 (ref) | 8 | 1393 | 2683 | 1.0 | 7 | 296 | 2548 | 1.0 | ||
| 25–29.9 | 8 | 6.2 | 1427 | 2566 | 1.02 (0.92–1.13) | 7 | 19.7 | 275 | 2409 | 1.13 (0.91–1.41) |
| 30–34.9 | 8 | 0.0 | 823 | 1335 | 1.17 (1.04–1.31) | 7 | 17.0 | 199 | 1236 | 1.58 (1.24–2.03) |
| 35–39.9 | 8 | 60.2 | 388 | 592 | 1.29 (0.99–1.68)* | 6 | 0.0 | 105 | 544 | 1.70 (1.30–2.22) |
| ≥40 | 8 | 15.9 | 310 | 490 | 1.16 (0.96–1.41) | 5 | 30.5 | 108 | 455 | 1.90 (1.35–2.68) |
| Per 5 kg/m2c | 8 | 45.3 | 1.06 (1.01–1.11) | 7 | 35.8 | 1.17 (1.08–1.26) | ||||
| BMI early adulthood | ||||||||||
| <18.5 | 14 | 0.0 | 1646 | 2931 | 0.94 (0.88–1.01) | 12 | 13.0 | 416 | 2718 | 0.97 (0.85–1.11) |
| 18.5–24.9 (ref) | 14 | 7278 | 12 364 | 1.0 | 12 | 1819 | 11 245 | 1.0 | ||
| 25–29.9 | 14 | 0.0 | 788 | 1151 | 1.12 (1.01–1.24) | 11 | 0.0 | 248 | 983 | 1.27 (1.09–1.49) |
| 30–34.9 | 14 | 0.0 | 176 | 233 | 1.21 (0.98–1.49) | 10 | 0.0 | 66 | 210 | 1.32 (0.98–1.78) |
| ≥35 | 12 | 0.0 | 76 | 108 | 1.08 (0.78–1.49) | 10 | 0.0 | 43 | 100 | 1.86 (1.25–2.78) |
| Per 5 kg/m2c | 14 | 1.08 (1.03–1.14) | 12 | 1.15 (1.08–1.24) | ||||||
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*Significant heterogeneity noted (P value for heterogeneity <0.05).
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↵a Stratified by age in 5-year groups and adjusted for parity (0, 1, 2, 3, 4+ full-term births), hormonal contraceptive use (0, ≤60 and >60 months), family history of breast or ovarian cancer in a first-degree relative and, where appropriate, race/ethnicity.
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↵b Numbers may not sum to total because of missing data.
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↵c Excludes women in the underweight range (BMI <18.5 kg/m2).
