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This Article Accepted manuscript (PDF) All Versions of this Article: ERC-08-0281v1 16/2/351    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dressing, G. Articles by Lange, C. Search for Related Content PubMed PubMed Citation Articles by Dressing, G. Articles by Lange, C.

G Dressing, Medicine and Pharmacology, University of Minnesota, Minneapolis, United States
C Hagan, Medicine and Pharmacology, University of Minnesota, Minneapolis, United States
T Knutson, Medicine and Pharmacology, University of Minnesota, Minneapolis, United States
A Daniel, Medicine and Pharmacology, University of Minnesota, Minneapolis, United States
C Lange, Medicine and Pharmacology, University of Minnesota, Minneapolis, United States

Correspondence: Gwen Dressing, Email: dress088{at}umn.edu

Abstract

Progesterone receptors (PR), members of the nuclear receptor superfamily, function as ligand-activated transcription factors and initiators of c-Src and mitogen activated protein kinase (MAPK) signaling. Bi-directional cross-talk between PR and mitogenic protein kinases results in changes in PR post-translational modification, leading to alterations in PR transcriptional activity and promoter selectivity. PR-induced rapid activation of cytoplasmic protein kinases insures precise regulatory input to downstream cellular processes that are dependent upon nuclear PR, such as cell cycle progression, , and pro-survival signaling.. Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell line models.