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This Article Accepted manuscript (PDF) All Versions of this Article: ERC-08-0094v1 15/3/693    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Karagiannis, A. Articles by Mikhailidis, D. Search for Related Content PubMed PubMed Citation Articles by Karagiannis, A. Articles by Mikhailidis, D.

A Karagiannis, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
K Tziomalos, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
A Kakafika, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
V Athyros, Second Propedeutic Department of Internal Medicine, Aristorle University of Thessaloniki, Thessaloniki, Greece
F Harsoulis, Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
D Mikhailidis, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free University, London, United Kingdom

Correspondence: Asterios Karagiannis, Email: astkar{at}med.auth.gr

Abstract

Primary aldosteronism (PA) and in particular its 2 commonest subtypes [i.e. idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA)] have been recognised as the most common cause of secondary hypertension. While "conservative" medical treatment with aldosterone receptor antagonists is the therapeutic approach of choice in controlling blood pressure (BP) in patients with PA due to IHA, the more invasive (laparoscopic) adrenalectomy seems to be the most suitable therapy for patients with APA. In this review we focus on the medical approach for the management of APA in cases where surgical excision of the adrenal is not possible.