| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancement of ligand-induced biological responses. These characteristics demonstrate the central role of ErbB2 in the receptor family, which likely explains why it is involved in the development of many human malignancies, including breast cancer. ErbB RTKs also function as signal integrators, cross-regulating different classes of membrane receptors including receptors of the cytokine family. Cross-regulation of ErbB RTKs and cytokines receptors represents another mechanism for controlling and enhancing tumor cell proliferation.
This article has been cited by other articles:
|
|
 |
|
  K.-P. Xu and F.-S. X. Yu Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2242 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xue, G. Hsieh, M. A. Raymond-Stintz, J. Pfeiffer, D. Roberts, S. L. Steinberg, J. M. Oliver, E. R. Prossnitz, D. S. Lidke, and B. S. Wilson Activated N-Formyl Peptide Receptor and High-Affinity IgE Receptor Occupy Common Domains for Signaling and Internalization Mol. Biol. Cell, April 1, 2007; 18(4): 1410 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yin, K. Xu, J. Zhang, A. Kumar, and F.-S. X. Yu Wound-induced ATP release and EGF receptor activation in epithelial cells J. Cell Sci., March 1, 2007; 120(5): 815 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Xu, J. Yin, and F.-S. X. Yu Lysophosphatidic Acid Promoting Corneal Epithelial Wound Healing by Transactivation of Epidermal Growth Factor Receptor Invest. Ophthalmol. Vis. Sci., February 1, 2007; 48(2): 636 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Xu, J. Yin, and F.-S. X. Yu SRC-family tyrosine kinases in wound- and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 2832 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Kauraniemi and A Kallioniemi Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer. Endocr. Relat. Cancer, March 1, 2006; 13(1): 39 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Tikhomirov and G. Carpenter Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death J. Cell Sci., December 15, 2005; 118(24): 5681 - 5690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Fontana, V. Choren, L. Vauthay, J. C. Calvo, L. Calvo, and M. Cameo Exogenous interferon-{gamma} alters murine inner cell mass and trophoblast development. Effect on the expression of ErbB1, ErbB4 and heparan sulfate proteoglycan (perlecan) Reproduction, December 1, 2004; 128(6): 717 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Herrlich, V. Leitch, and L. S. King Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction PNAS, November 2, 2004; 101(44): 15799 - 15804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Bill, B. Knudsen, S. L. Moores, S. K. Muthuswamy, V. R. Rao, J. S. Brugge, and C. K. Miranti Epidermal Growth Factor Receptor-Dependent Regulation of Integrin-Mediated Signaling and Cell Cycle Entry in Epithelial Cells Mol. Cell. Biol., October 1, 2004; 24(19): 8586 - 8599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, H. Li, J. Wang, Z. Dong, S. Mian, and F.-S. X. Yu Role of EGFR Transactivation in Preventing Apoptosis in Pseudomonas aeruginosa-Infected Human Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2569 - 2576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Tikhomirov and G. Carpenter Ligand-induced, p38-dependent Apoptosis in Cells Expressing High Levels of Epidermal Growth Factor Receptor and ErbB-2 J. Biol. Chem., March 26, 2004; 279(13): 12988 - 12996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Xu, Y. Ding, J. Ling, Z. Dong, and F.-S. X. Yu Wound-Induced HB-EGF Ectodomain Shedding and EGFR Activation in Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., March 1, 2004; 45(3): 813 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kari, T. O. Chan, M. Rocha de Quadros, and U. Rodeck Targeting the Epidermal Growth Factor Receptor in Cancer: Apoptosis Takes Center Stage Cancer Res., January 1, 2003; 63(1): 1 - 5. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. D. Johnston, J. Head, S. Pancholi, S. Detre, L.-A. Martin, I. E. Smith, and M. Dowsett Integration of Signal Transduction Inhibitors with Endocrine Therapy: An Approach to Overcoming Hormone Resistance in Breast Cancer Clin. Cancer Res., January 1, 2003; 9(1): 524S - 532S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Rusnak, K. Lackey, K. Affleck, E. R. Wood, K. J. Alligood, N. Rhodes, B. R. Keith, D. M. Murray, W. B. Knight, R. J. Mullin, et al. The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo Mol. Cancer Ther., December 1, 2001; 1(2): 85 - 94. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
