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Endocrine-Related Cancer 8 (1) 11 -31     DOI: 10.1677/erc.0.0080011
Copyright © 2001 by the Society for Endocrinology
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Endocrine Related Cancer, Vol 8, Issue 1, 11-31
Copyright © 2001 by Society for Endocrinology


Articles

The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification

N Prenzel, OM Fischer, S Streit, S Hart, and A Ullrich


Homeostasis of multicellular organisms is critically dependent on the correct interpretation of the plethora of signals which cells are exposed to during their lifespan. Various soluble factors regulate the activation state of cellular receptors which are coupled to a complex signal transduction network that ultimately generates signals defining the required biological response. The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases represents both key regulators of normal cellular development as well as critical players in a variety of pathophysiological phenomena. The aim of this review is to give a broad overview of signal transduction networks that are controlled by the EGFR superfamily of receptors in health and disease and its application for target-selective therapeutic intervention. Since the EGFR and HER2 were recently identified as critical players in the transduction of signals by a variety of cell surface receptors, such as G-protein-coupled receptors and integrins, our special focus is the mechanisms and significance of the interconnectivity between heterologous signalling systems.


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[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. W. Werneburg, J.-H. Yoon, H. Higuchi, and G. J. Gores
Bile acids activate EGF receptor via a TGF-{alpha}-dependent mechanism in human cholangiocyte cell lines
Am J Physiol Gastrointest Liver Physiol, June 9, 2003; 285(1): G31 - G36.
[Abstract] [Full Text] [PDF]


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Mol. Interv.Home page
Z. Xie and T. Cai
Na+-K+-ATPase-Mediated Signal Transduction: From Protein Interaction to Cellular Function
Mol. Interv., May 1, 2003; 3(3): 157 - 168.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
A. Derrien, B. Zheng, J. L. Osterhout, Y.-C. Ma, G. Milligan, M. G. Farquhar, and K. M. Druey
Src-mediated RGS16 Tyrosine Phosphorylation Promotes RGS16 Stability
J. Biol. Chem., April 25, 2003; 278(18): 16107 - 16116.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
A. A. Jungbluth, E. Stockert, H. J. S. Huang, V. P. Collins, K. Coplan, K. Iversen, D. Kolb, T. J. Johns, A. M. Scott, W. J. Gullick, et al.
A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor
PNAS, January 21, 2003; 100(2): 639 - 644.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
A. V. Lee, R. Schiff, X. Cui, D. Sachdev, D. Yee, A. P. Gilmore, C. H. Streuli, S. Oesterreich, and D. L. Hadsell
New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transactivation
Clin. Cancer Res., January 1, 2003; 9(1): 516s - 523s.
[Abstract] [Full Text]


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Proc. Natl. Acad. Sci. USAHome page
S. J. Fleishman, J. Schlessinger, and N. Ben-Tal
A putative molecular-activation switch in the transmembrane domain of erbB2
PNAS, December 10, 2002; 99(25): 15937 - 15940.
[Abstract] [Full Text] [PDF]


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IOVSHome page
K.-P. Xu, D. A. Dartt, and F.-S. X. Yu
EGF-Induced ERK Phosphorylation Independent of PKC Isozymes in Human Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci., December 1, 2002; 43(12): 3673 - 3679.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
A. Gschwind, N. Prenzel, and A. Ullrich
Lysophosphatidic Acid-induced Squamous Cell Carcinoma Cell Proliferation and Motility Involves Epidermal Growth Factor Receptor Signal Transactivation
Cancer Res., November 1, 2002; 62(21): 6329 - 6336.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. Gogg and U. Smith
Epidermal Growth Factor and Transforming Growth Factor alpha Mimic the Effects of Insulin in Human Fat Cells and Augment Downstream Signaling in Insulin Resistance
J. Biol. Chem., September 20, 2002; 277(39): 36045 - 36051.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
J. Cheng, H. Huang, Z.-T. Zhang, E. Shapiro, A. Pellicer, T.-T. Sun, and X.-R. Wu
Overexpression of Epidermal Growth Factor Receptor in Urothelium Elicits Urothelial Hyperplasia and Promotes Bladder Tumor Growth
Cancer Res., July 15, 2002; 62(14): 4157 - 4163.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
W. Wu, L. M. Graves, G. N. Gill, S. J. Parsons, and J. M. Samet
Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor on Tyrosine 845 Is Required for Zinc-induced Ras Activation
J. Biol. Chem., June 28, 2002; 277(27): 24252 - 24257.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. Haas, H. Wang, J. Tian, and Z. Xie
Src-mediated Inter-receptor Cross-talk between the Na+/K+-ATPase and the Epidermal Growth Factor Receptor Relays the Signal from Ouabain to Mitogen-activated Protein Kinases
J. Biol. Chem., May 17, 2002; 277(21): 18694 - 18702.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. J. DiCamillo, I. Carreras, M. V. Panchenko, P. J. Stone, M. A. Nugent, J. A. Foster, and M. P. Panchenko
Elastase-released Epidermal Growth Factor Recruits Epidermal Growth Factor Receptor and Extracellular Signal-regulated Kinases to Down-regulate Tropoelastin mRNA in Lung Fibroblasts
J. Biol. Chem., May 17, 2002; 277(21): 18938 - 18946.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
R. Hemi, K. Paz, N. Wertheim, A. Karasik, Y. Zick, and H. Kanety
Transactivation of ErbB2 and ErbB3 by Tumor Necrosis Factor-alpha and Anisomycin Leads to Impaired Insulin Signaling through Serine/Threonine Phosphorylation of IRS Proteins
J. Biol. Chem., March 8, 2002; 277(11): 8961 - 8969.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
D. G. Thomas, T. J. Giordano, D. Sanders, J. S. Biermann, and L. Baker
Absence of HER2/neu Gene Expression in Osteosarcoma and Skeletal Ewing's Sarcoma
Clin. Cancer Res., March 1, 2002; 8(3): 788 - 793.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
W. G. Thomas, Y. Brandenburger, D. J. Autelitano, T. Pham, H. Qian, and R. D. Hannan
Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor
Circ. Res., February 8, 2002; 90(2): 135 - 142.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. Klingler-Hoffmann, M. T. Fodero-Tavoletti, K. Mishima, Y. Narita, W. K. Cavenee, F. B. Furnari, H.-J. S. Huang, and T. Tiganis
The Protein Tyrosine Phosphatase TCPTP Suppresses the Tumorigenicity of Glioblastoma Cells Expressing a Mutant Epidermal Growth Factor Receptor
J. Biol. Chem., November 30, 2001; 276(49): 46313 - 46318.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
W. G. Thomas, Y. Brandenburger, D. J. Autelitano, T. Pham, H. Qian, and R. D. Hannan
Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor
Circ. Res., February 8, 2002; 90(2): 135 - 142.
[Abstract] [Full Text] [PDF]




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