As we begin the new millennium, it is a great privilege for me to assume the responsibility of Editor-in-Chief of Endocrine-Related Cancer. As members of the Society for Endocrinology will know, Endocrine-Related Cancer< represents the further development and expansion of Reviews on Endocrine-Related Cancer which was acquired by the Society in 1993. Under the brilliant stewardship of its founding editor, Vivian James, Endocrine-Related Cancer has grown to be an outstanding journal publishing significant reviews in the area of intersection between endocrinology and cancer as well as proceedings of important scientific meetings and symposia around the world.