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Endocrine-Related Cancer 6 (1) 69-73    DOI: 10.1677/erc.0.0060069
Copyright © 1999 by the Society for Endocrinology.
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Endocrine Related Cancer, Vol 6, Issue 1, 69-73
Copyright © 1999 by Society for Endocrinology

Articles

Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment

NE Davidson, HA Hahm, DE McCloskey, PM Woster, and Casero RA Jr


Because intracellular polyamines have a critical role in cell proliferation and death pathways, the polyamine metabolic pathway represents a potential target for intervention in cancers. A number of polyamine analogues have been identified that downregulate polyamine synthesis and enhance polyamine catabolism, thereby depleting intracellular polyamines. Treatment of human breast cancer cell lines in culture with these analogues has been shown to decrease cell proliferation and induce programmed cell death. Phase I studies with one analogue are now complete, setting the stage for phase II trials to determine efficacy, in addition to preclinical studies to examine combinations of polyamine analogues and conventional cytotoxics.


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Copyright © 1999 by the Society for Endocrinology.