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This Article Full Text Full Text (PDF) All Versions of this Article: ERC-09-0262v1 17/1/R39    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Khan, N. Articles by Mukhtar, H. Search for Related Content PubMed PubMed Citation Articles by Khan, N. Articles by Mukhtar, H.

Department of Dermatology, Medical Sciences Center, University of Wisconsin-Madison, 4385, 1300 University Avenue, Madison, Wisconsin 53706, USA

(Correspondence should be addressed to H Mukhtar; Email: hmukhtar{at}wisc.edu)

Accumulating data clearly indicate that induction of apoptosis is an important event for chemoprevention of cancer by naturally occurring dietary agents. In mammalian cells, apoptosis has been divided into two major pathways: the extrinsic pathway, activated by pro-apoptotic receptor signals at the cellular surface; and the intrinsic pathway, which involves the disruption of mitochondrial membrane integrity. This process is strictly controlled in response to integrity of pro-death signaling and plays critical roles in development, maintenance of homeostasis, and host defense in multicellular organisms. For chemoprevention studies, prostate cancer (PCa) represents an ideal disease due to its long latency, its high incidence, tumor marker availability, and identifiable preneoplastic lesions and risk groups. In this article, we highlight the studies of various apoptosis-inducing dietary compounds for prevention of PCa in vitro in cell culture, in preclinical studies in animals, and in human clinical trials.