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This Article Full Text Full Text (PDF) All Versions of this Article: ERC-09-0109v1 16/3/663    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Vindrieux, D. Articles by Lazennec, G. PubMed PubMed Citation Articles by Vindrieux, D. Articles by Lazennec, G.

¹ INSERM, U844, Site Saint Eloi, Bâtiment INM, 80 rue Augustin Fliche, Montpellier F-34091, France
² University of Montpellier I, Montpellier F-34090, France

(Correspondence should be addressed to G Lazennec, INSERM, U844, Site Saint Eloi, 80 rue Augustin Fliche, 34295 Montpellier, France; Email: gwendal.lazennec{at}inserm.fr)

Prostate cancer (PCa) represents the second leading cause of death among all cancer types in men in Europe and North America. Among the factors suspected to control PCa, incidence and progression, chemokines, and their receptors are now intensively studied. Chemokines are produced by tumor cells and also by the stromal microenvironment, both in the primary tumor site and in distant metastatic locations. The wide and differential distribution of chemokines and their receptors account for the pleiotropic actions of chemokines in PCa, including the modulation of growth, angiogenesis, invasion, metastasis, and hormone escape. This review will focus on the roles and the mechanisms of action and regulation of chemokines in the different steps of PCa development and will discuss the novel strategies that are currently envisioned to target chemokines in PCa.