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This Article Full Text Full Text (PDF) All Versions of this Article: ERC-08-0094v1 15/3/693    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Karagiannis, A. Articles by Mikhailidis, D. P PubMed PubMed Citation Articles by Karagiannis, A. Articles by Mikhailidis, D. P

¹ Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece² Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital Campus, University College London (UCL), Pond Street, London NW3 2QG, UK

(Correspondence should be addressed to D P Mikhailidis; Email: mikhailidis{at}aol.com)

Primary aldosteronism (PA) and, in particular, its two commonest subtypes (i.e. idiopathic hyperaldosteronism (IHA) and aldosterone-producing adenoma (APA)) have been recognized as the most common cause of secondary hypertension. While ‘conservative’ medical treatment with aldosterone receptor antagonists is the therapeutic approach of choice in controlling blood pressure in patients with PA due to IHA, the more invasive (laparoscopic) adrenalectomy seems to be the most suitable therapy for patients with APA. In this review, we focus on the medical approach for the management of APA in cases where surgical excision of the adrenal is not possible.