HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Tian, Y.-F. Articles by Sun, C.-A. Search for Related Content PubMed PubMed Citation Articles by Tian, Y.-F. Articles by Sun, C.-A.

Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
¹ Headquarter, National Defense Medical Center, Taipei, Taiwan
² Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
³ School of Public Health, National Defense Medical Center, Taipei, Taiwan
⁴ Graduate Institute of Health Care, Meiho Institute of Technology, Pingtung, Taiwan
⁵ Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan
⁶ Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan
⁷ Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan

(Correspondence should be addressed to C-A Sun; Email: sunca{at}mail.ndmctsgh.edu.tw)

Y-F Tian and C-H Chu contributed equally to this paper

Adiponectin is a peptide hormone secreted exclusively by adipocytes, and obesity is an established risk factor for breast cancer. We have, thus, evaluated the associations of anthropometric measures of adiposity and adiponectin with the development of breast cancer in a case–control study. Questionnaire information, anthropometric measures, and blood samples were taken before treatment from 244 incident cases with breast cancer, including 141 premenopausal and 103 postmenopausal cases, and 244 controls admitted for health examination at the Tri-Service General Hospital, Taipei between 2004 and 2005. Plasma levels of adiponectin were measured by RIA. The relationship between anthropometric measures of adiposity and breast cancer risk was modified by menopausal status, with a significant increase in risk observed in postmenopausal but not premenopausal women. Moreover, a fairly robust inverse association of adiponectin with the risk was observed only in postmenopausal women (adjusted odds ratio (OR), 0.55; 95% confidence interval (CI), 0.23–0.97), but not in premenopausal women. Additionally, the plasma adiponectin levels tended to be inversely associated with estrogen receptor (ER)-positive (adjusted OR, 0.53; 95% CI, 0.27–0.98) but not ER-negative breast tumors. Furthermore, the associations of adiponectin with breast cancer risk overall and by menopausal and ER status remained after adjustment for obesity indices. These results suggest that adiponectin may have an independent role in breast carcinogenesis, particularly in the postmenopausal and ER-positive breast cancer risk.

This article has been cited by other articles:

				H. K. Neilson, C. M. Friedenreich, N. T. Brockton, and R. C. Millikan Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 11 - 27. [Abstract] [Full Text] [PDF]