HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Link to related commentary Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rinaldi, S Articles by Kaaks, R Search for Related Content PubMed PubMed Citation Articles by Rinaldi, S Articles by Kaaks, R

¹ International Agency for Research on Cancer (IARC-WHO), 150 Cours Albert Thomas, 69372 Lyon, Cédex 08, France
² Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands
³ National Cancer Institute, Milan, Italy
⁴ The Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
⁵ Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
⁶ INSERM, Institut Gustave Roussy, Villejuif, France
⁷ Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
⁸ German Institute of Human Nutrition, Department of Epidemiology, Potsdam-Rehbrücke, Germany
⁹ University of Athens Medical School, Athens, Greece
¹⁰ Molecular and Nutritional Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy
¹¹ Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
¹² Cancer Registry, Azienda Ospedaliera ‘Civile M P Arezzo’, Ragusa, Italy
¹³ CPO-Piemonte, Torino, Italy
¹⁴ Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
¹⁵ Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain
¹⁶ Epidemiology Department, Murcia Health Council, Murcia, Spain
¹⁷ Public Health Institute of Navarra, Pamplona, Spain
¹⁸ Public Health Division of Gipuzkoa, Health Department of the Basque Country, Donostia-San Sebastian, Spain
¹⁹ Public Health and Health Planning Directorate, Asturias, Spain
²⁰ MRC Centre for Nutrition in Cancer Prevention and Survival, University of Cambridge, Department of Public Health and Primary Care, Cambridge, United Kingdom
²¹ Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom
²² Epidemiology Unit, Cancer Research UK, University of Oxford, Oxford, United Kingdom
²³ New York University School of Medicine, New York, USA
²⁴ Imperial College, London, United Kingdom

(Requests for offprints should be addressed to R Kaaks; Email: kaaks{at}iarc.fr)

Blood concentrations of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) have recently been associated with breast cancer risk, notably in women who developed breast cancer at a young age. Prospective studies published so far, however, were relatively small and odds ratio (OR) estimates imprecise. We present the results of a large prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition on total IGF-I, IGFBP-3 and breast cancer risk including 1081 incident cases of invasive breast cancer and 2098 matched control subjects. Increasing IGF-I and IGFBP-3 concentrations were associated with a significant increase in breast cancer risk in women who developed breast cancer after 50 years of age (highest vs lowest quintile OR 1.38 (95% confidence interval (CI) 1.02–1.86), P = 0.01, and 1.44 (95% CI 1.04–1.98), P = 0.01, respectively), but no relationship was observed in younger women (OR = 1.03 (95% CI 0.60–1.77), P = 0.81 for IGF-I, and OR = 0.92 (95% CI 0.50–1.70), P = 0.69 for IGFBP-3). There was, however, significant heterogeneity in the relationship of breast cancer with serum IGF-I and IGFBP-3 levels depending on the time interval between blood donation and tumor diagnosis. A reduction in breast cancer risk with increasing IGF-I concentrations was observed in cases with a diagnosis of cancer less than 2 years after blood donation, (OR = 0.76 (95% CI 0.57–1.03)), while an increase in risk was observed for women with a later diagnosis (above or equal to two years after blood collection, OR = 1.51 (95% CI 1.19–1.91)). A similar pattern was observed for IGFBP-3. This study confirms previous findings for an association of serum IGF-I and IGFBP-3 concentrations with breast cancer risk, particularly for women with a later diagnosis of cancer, but it does not support the hypothesis of an involvement of IGF-I in younger women.

This article has been cited by other articles:

				L. J. Vatten, J. M. Holly, D. Gunnell, and S. Tretli Nested Case-Control Study of the Association of Circulating Levels of Serum Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 with Breast Cancer in Young Women in Norway Cancer Epidemiol. Biomarkers Prev., August 1, 2008; 17(8): 2097 - 2100. [Abstract] [Full Text] [PDF]

				L. Dossus, J. D. McKay, F. Canzian, S. Wilkening, S. Rinaldi, C. Biessy, A. Olsen, A. Tjonneland, M. U. Jakobsen, K. Overvad, et al. Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Carcinogenesis, July 1, 2008; 29(7): 1360 - 1366. [Abstract] [Full Text] [PDF]

				V. M. Chia, S. M. Quraishi, B. I. Graubard, M. V. Rubertone, R. L. Erickson, F. Z. Stanczyk, and K. A. McGlynn Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk Am. J. Epidemiol., June 15, 2008; 167(12): 1438 - 1445. [Abstract] [Full Text] [PDF]

				S. S. Maruti, W. C. Willett, D. Feskanich, B. Rosner, and G. A. Colditz A Prospective Study of Age-Specific Physical Activity and Premenopausal Breast Cancer J Natl Cancer Inst, May 21, 2008; 100(10): 728 - 737. [Abstract] [Full Text] [PDF]

				E. S Schernhammer, S. S Tworoger, A H. Eliassen, S. A Missmer, J. M Holly, M. N Pollak, and S. E Hankinson Body shape throughout life and correlations with IGFs and GH Endocr. Relat. Cancer, September 1, 2007; 14(3): 721 - 732. [Abstract] [Full Text] [PDF]

				I. Cheng, K. DeLellis Henderson, C. A. Haiman, L. N. Kolonel, B. E. Henderson, M. L. Freedman, and L. Le Marchand Genetic Determinants of Circulating Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein (BP)-1, and IGFBP-3 Levels in a Multiethnic Population J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3660 - 3666. [Abstract] [Full Text] [PDF]

				L. Baglietto, D. R. English, J. L. Hopper, H. A. Morris, W. D. Tilley, and G. G. Giles Circulating Insulin-Like Growth Factor-I and Binding Protein-3 and the Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 763 - 768. [Abstract] [Full Text] [PDF]

				M. Verheus, P. H.M. Peeters, R. Kaaks, P. A.H. van Noord, D. E. Grobbee, and C. H. van Gils Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 451 - 457. [Abstract] [Full Text] [PDF]

				K. Pazaitou-Panayiotou, T. Kelesidis, I. Kelesidis, A. Kaprara, J. Blakeman, I. Vainas, A. Mpousoulegas, C. J Williams, and C. Mantzoros Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer Eur. J. Endocrinol., February 1, 2007; 156(2): 187 - 194. [Abstract] [Full Text] [PDF]

				Y. Bremnes, G. Ursin, N. Bjurstam, S. Rinaldi, R. Kaaks, and I. T. Gram Insulin-like Growth Factor and Mammographic Density in Postmenopausal Norwegian Women Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 57 - 62. [Abstract] [Full Text] [PDF]

				A. Lukanova, P. Toniolo, A. Zeleniuch-Jacquotte, K. Grankvist, M. Wulff, A. A. Arslan, Y. Afanasyeva, R. Johansson, P. Lenner, G. Hallmans, et al. Insulin-like Growth Factor I in Pregnancy and Maternal Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2489 - 2493. [Abstract] [Full Text] [PDF]

				A. G Renehan, M. Harvie, and A. Howell Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on. Endocr. Relat. Cancer, June 1, 2006; 13(2): 273 - 278. [Abstract] [Full Text] [PDF]