HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Free Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lorincz, A M Articles by Sukumar, S Search for Related Content PubMed PubMed Citation Articles by Lorincz, A M Articles by Sukumar, S

¹ Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 410 CRB, Baltimore, MD 21231-1000, USA
² Graduate Program in Pathobiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

(Requests for offprints should be addressed to S Sukumar at first address; Email: saras{at}jhmi.edu)

Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.

This article has been cited by other articles:

				L. R. Teras, M. Goodman, A. V. Patel, M. Bouzyk, W. Tang, W. R. Diver, and H. S. Feigelson No Association between Polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and Postmenopausal Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2553 - 2557. [Abstract] [Full Text] [PDF]

				M. P. Cleary and M. E. Grossmann Obesity and Breast Cancer: The Estrogen Connection Endocrinology, June 1, 2009; 150(6): 2537 - 2542. [Abstract] [Full Text] [PDF]

				S. Landskroner-Eiger, B. Qian, E. S. Muise, A. R. Nawrocki, J. P. Berger, E. J. Fine, W. Koba, Y. Deng, J. W. Pollard, and P. E. Scherer Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo Clin. Cancer Res., May 15, 2009; 15(10): 3265 - 3276. [Abstract] [Full Text] [PDF]

				H. K. Neilson, C. M. Friedenreich, N. T. Brockton, and R. C. Millikan Physical Activity and Postmenopausal Breast Cancer: Proposed Biologic Mechanisms and Areas for Future Research Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 11 - 27. [Abstract] [Full Text] [PDF]

				F. Formelli, E. Meneghini, E. Cavadini, T. Camerini, M. G. Di Mauro, G. De Palo, U. Veronesi, F. Berrino, and A. Micheli Plasma Retinol and Prognosis of Postmenopausal Breast Cancer Patients Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 42 - 48. [Abstract] [Full Text] [PDF]

				H. Johansson, S. Gandini, A. Guerrieri-Gonzaga, S. Iodice, M. Ruscica, B. Bonanni, M. Gulisano, P. Magni, F. Formelli, and A. Decensi Effect of Fenretinide and Low-Dose Tamoxifen on Insulin Sensitivity in Premenopausal Women at High Risk for Breast Cancer Cancer Res., November 15, 2008; 68(22): 9512 - 9518. [Abstract] [Full Text] [PDF]

				C. N Perera, H. G Chin, N. Duru, and I. G Camarillo Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression J. Endocrinol., November 1, 2008; 199(2): 221 - 233. [Abstract] [Full Text] [PDF]

				J. Liu, J. B.B. Lam, K. H.M. Chow, A. Xu, K. S.L. Lam, R. T. Moon, and Y. Wang Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1 Carcinogenesis, November 1, 2008; 29(11): 2195 - 2202. [Abstract] [Full Text] [PDF]

				C M Friedenreich and A E Cust Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects Br. J. Sports Med., August 1, 2008; 42(8): 636 - 647. [Abstract] [Full Text] [PDF]

				V. Bartella, S. Cascio, E. Fiorio, A. Auriemma, A. Russo, and E. Surmacz Insulin-Dependent Leptin Expression in Breast Cancer Cells Cancer Res., June 15, 2008; 68(12): 4919 - 4927. [Abstract] [Full Text] [PDF]

				C. N. Perera, H. S. Spalding, S. I. Mohammed, and I. G. Camarillo Identification of Proteins Secreted from Leptin Stimulated MCF-7 Breast Cancer Cells: A Dual Proteomic Approach Experimental Biology and Medicine, June 1, 2008; 233(6): 708 - 720. [Abstract] [Full Text] [PDF]

				Y.-P. Lu, B. Nolan, Y.-R. Lou, Q.-Y. Peng, G. C. Wagner, and A. H. Conney Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice PNAS, July 31, 2007; 104(31): 12936 - 12941. [Abstract] [Full Text] [PDF]

				L. Mauro, S. Catalano, G. Bossi, M. Pellegrino, I. Barone, S. Morales, C. Giordano, V. Bartella, I. Casaburi, and S. Ando Evidences that Leptin Up-regulates E-Cadherin Expression in Breast Cancer: Effects on Tumor Growth and Progression Cancer Res., April 1, 2007; 67(7): 3412 - 3421. [Abstract] [Full Text] [PDF]