|
|
||||||||
REVIEW |
1 Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 410 CRB, Baltimore, MD 21231-1000, USA
2 Graduate Program in Pathobiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
(Requests for offprints should be addressed to S Sukumar at first address; Email: saras{at}jhmi.edu)
Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.
This article has been cited by other articles:
![]() |
C M Friedenreich and A E Cust Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects Br. J. Sports Med., August 1, 2008; 42(8): 636 - 647. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Bartella, S. Cascio, E. Fiorio, A. Auriemma, A. Russo, and E. Surmacz Insulin-Dependent Leptin Expression in Breast Cancer Cells Cancer Res., June 15, 2008; 68(12): 4919 - 4927. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. N. Perera, H. S. Spalding, S. I. Mohammed, and I. G. Camarillo Identification of Proteins Secreted from Leptin Stimulated MCF-7 Breast Cancer Cells: A Dual Proteomic Approach Experimental Biology and Medicine, June 1, 2008; 233(6): 708 - 720. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-P. Lu, B. Nolan, Y.-R. Lou, Q.-Y. Peng, G. C. Wagner, and A. H. Conney Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice PNAS, July 31, 2007; 104(31): 12936 - 12941. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Mauro, S. Catalano, G. Bossi, M. Pellegrino, I. Barone, S. Morales, C. Giordano, V. Bartella, I. Casaburi, and S. Ando Evidences that Leptin Up-regulates E-Cadherin Expression in Breast Cancer: Effects on Tumor Growth and Progression Cancer Res., April 1, 2007; 67(7): 3412 - 3421. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |