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Endocrine-Related Cancer 12 (Supplement_1) S17 -27     DOI: 10.1677/erc.1.01032
Copyright © 2005 by the Society for Endocrinology
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The epidermal growth factor receptor family

L A Bazley and W J Gullick

Cancer Biology Laboratory, Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK

(Requests for offprints should be addressed to W J Gullick; Email: W.J.Gullick{at}kent.ac.uk)

This paper was presented at the 1st Tenovus/AstraZeneca Workshop, Cardiff (2005). AstraZeneca has supported the publication of these proceedings.

The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms. They create an interacting system that has the ability to receive and process information that results in multiple outputs. The family has an important role in directing and coordinating many normal processes, including growth and development, normal tissue turnover and wound healing. Its members are also aberrantly activated by overexpression or mutation in many common human tumour types and as such have been the target for anticancer drug development.




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