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Endocrine-Related Cancer 11 (2) 255 -263     DOI: 10.1677/erc.0.0110255
Copyright © 2004 by the Society for Endocrinology
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Endocrine Related Cancer, Vol 11, Issue 2, 255-263
Copyright © 2004 by Society for Endocrinology

Articles

Copper deficiency as an anti-cancer strategy

VL Goodman, GJ Brewer, and SD Merajver


Copper is a tightly regulated trace element. Disruptions of copper homeostasis are rare and they cause serious disorders such as Wilson's disease and Menkes disease. Copper also plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumor enables tumor growth, invasion and metastasis. The copper chelator tetrathiomolybdate (TM), which quickly and effectively depletes copper stores, is under investigation as an anti-angiogenic agent. Promising results in vitro, in pre-clinical animal models and in an early (phase I) clinical trial have led to ongoing phase II evaluation of TM in patients with advanced cancers.


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