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Endocrine-Related Cancer 10 (4) 427-436    DOI: 10.1677/erc.0.0100427
Copyright © 2003 by the Society for Endocrinology.
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Endocrine Related Cancer, Vol 10, Issue 4, 427-436
Copyright © 2003 by Society for Endocrinology

Articles

Highlights of the biology of endocrine tumours of the gut and pancreas

G Rindi and C Bordi


Originating from cells of the diffuse endocrine system the endocrine tumours of the gut and the pancreatic tract are rare entities characterized by a common phenotypic aspect and producing several bioactive substances including growth factors. Two major categories are identified: well-differentiated and poorly differentiated tumours. The clinical behaviour varies ranging from benign to low grade malignant for well-differentiated tumours/carcinomas to high grade malignant for poorly differentiated carcinomas. The two major categories of well-differentiated and poorly differentiated tumours display distinct phenotypes and genetic backgrounds possibly supporting distinct histogenesis. Genetic abnormalities associated with either induction or progression of tumours may vary depending on the site of origin.


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